Shopping Jane Deals 2/6

 Shopping was never made easier than to shop online and at there are amazing products, clothing, home decor,
mens, children’s and women’s clothing plus shoes. So today I am sharing some great deals that are just available.
All deals are from Start: 02/06/2019 and End: 02/15/2019Jane Online Shopping Deals 2-6-2019

 #1.  Bill Tracker & 411 Journal | Was $19.99 Ships for $13.99  Ends 2/9
#2.  Perfect Colored Bermudas | S-3XL – Was $34.99 – Ships for $18.48! Ends 2/9
#3.  Women’s Embroidered Tops |  Was $59.99 – Ships for $20.99!  Ends 2/9
#4  Everyday Striped Tunic Blowout – Was $29.99 – Ships for $11.98! Ends 2/10
#5   Nope/Not Today Tees – Was $25.00 – Ships for $17.98!
#6. Glow In The Dark PicassoTiles | Free Shipping – Was $99.99 – Now $54.99  Ends 2/10Save Money On Every DayShopping Jane Online Boutique SpecialsAll deals are from Start: 02/06/2019 and End: 02/15/2019 So shop now to get the best deals.
I bring you these specials and they do contain affiliate links and I might receive compensation if you make a purchase after clicking on a link.

Keeping Your Smile White and Your Mouth Healthy

Let’s face it, life gets messy. With all the different foods, drinks, and late nights in life, sometimes your oral health can take the backseat. But, with Snow, you can feel good about living life and still have a beautiful, healthy smile.Keeping Your Teeth White and Your Mouth Healthy

Snow proudly offers fast and incredible results that put other teeth whitening methods to shame.

With unique, revolutionary technology, Snow whitens smarter and better than other at home teeth whitening systems. A doctor-formulated whitening serum combines with unique LED light technology to bring users dazzling white smiles that dentists and consumers alike approve of.

Snow customers are extremely positive and happy with their white teeth and it shows

Snow is such an easy system to use! The whitening kit comes with everything you need along with clear, easy to understand instructions to ensure you get the smile you’re after.

All you have to do is apply the whitening serum on your teeth, insert the mouthpiece for ten minutes, then rinse. It couldn’t be simpler and with Snow’s new wireless and waterproof mouthpiece, you can even whiten in the shower! Snow’s whitening kit is not only effective but super convenient and easy to use, making it a must-have for all of your whitening needs.

Snow’s new kit also does more than just whiten. Red light therapy focuses on gum circulation and helps to eliminate bacteria that causes gum disease. Dental visits can get pricey really quickly and if we’re being honest, does anyone really like going? By utilizing both the whitening and gum treatment features in this revolutionary whitening kit, you will be able to cut down on dental visits significantly.

Many teeth whitening methods are known to cause pain and sensitivity to teeth, making the process very uncomfortable. Snow, however, causes no pain or sensitivity! For those with extremely sensitive teeth, however, they offer a desensitizing serum just in case.

Snow is FDA approved and you don’t need a prescription to use it either! This system is available to all, plus shipping is free for U.S. orders!

Snow’s system is really hard to beat, especially with their new improvements to their whitening kit. Snow didn’t stop there, though. The company took into consideration other aspects that will make your teeth whitening experience even better. So, Snow also offers an activated charcoal floss and lip products including an exfoliant and anti-aging treatment.

Snow is dedicated to giving their customers a whitening experience they will enjoy using. With so many happy customers and a 100% results guarantee, they have done just that!

So, don’t let your oral health or yellow smile keep you from living your life; pick up Snow and keep on living.

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4 Steps You Can Take to Achieve a Celebrity Smile

Oh My Heartsie Girls Wonderful Wednesday

Oh My Heartsie Girls Wonderful  Wednesday” began 145 weeks ago and this week we are sharing new features that our Co-Hosts have chosen from the previous week’s links. I am sure that you will find it both fun and interesting to meet and make friends with bloggers from around the world through our party and appreciate your visit today! We are honored to have visitors from the USA, Spain, South Africa, Germany, Australia, Asia, Europe, UK  and more!!!
Where do you blog from?Oh-My-Heartsie-Girls-WWOh My Heartsie Girl & Co-Hosts Welcome’s you!! Where we start early ❢❢ 

:❢:❢ And if you looking for something special from last week, you Can See All The Entries Here :❢:❢ Oh My Heartsie Girls Wonderful WednesdayWe look forward to your recipes, reviews, DIY crafts, gardening hints, travel, beauty ideas, jewelry you make,
paper crafts you have made and Linky Parties,

We Want To See It All! And Please Feel Free To Pin A Few From Original Source
:❢ Be Notified When Our Parties Start Each Week Add Your Email Unsubscribe Anytime ❢:  
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 ♥~ MEET THE HOSTS of #OMHGWW ~5 Cool Things to Do in Havana, CubaIndah Nuria Savitri // My Purple World
5 Cool Things to Do in Havana, Cuba
So, what do you have in mind when you heard the word Havana?
The famous cigar? Fidel Castro?
Classic cars? Ernest Hemingway?
Beautiful beaches and lovely sea lanes? Salsa all night long?
Or all of them?

Twitter | Facebook | Pinterest | Instagram
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5 Tips to Edit Your Wardrobe and Personalize Your StyleKarren Haller // Oh My Heartsie Girl
5 Tips to Edit Your Wardrobe and Personalize Your Style

Twitter | Bloglovin | Facebook | Pinterest | InstagramDivider 989321gyey13hzitHow To Make Home Organization Easier and End ClutterClearissa Coward // Command Center
How To Make Home Organization Easier and End Clutter
Clearissa is a lifestyle blogger with an emphasis on organization,
DIYing, decorating, crafting and living a life filled with beauty and joy on a budget. 

Twitter | Instagram |Facebook |Pinterest
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How I use Coconut OilAlice V // DIYerfy
How I use Coconut Oil 
5 ways I use coconut oil in my daily life and
how you can incorporate this heart-healthy oil into your life too.

Instagram  Facebook |Pinterest
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DIY Homemade Castile SoapAmy// Hippy and a Redneck
DIY Homemade Castile Soap // I love Castile soap.
And I love my DIY homemade Castile Soap even more. Why?
Because I get to control what goes into it and the scents I choose.

Twitter | Facebook | Pinterest | Instagram  Divider 989321gyey13hzitSimple Blueberry MuffinsKaycee Mason // My Crafty Zoo
Simple Blueberry Muffins // 
There’s nothing like a peaceful morning
cup of coffee with fresh, homemade blueberry muffins!
This recipe is easily modified for any other fruit as well!

Twitter | Instagram |Facebook |Pinterest  
Divider 989321gyey13hzitPeanut Pretzel Bark♥ Suzan White // Country Crafting
Peanut Pretzel Bark // 
I was looking for an easy candy to
make with my granddaughters. Hailie is an experienced
cook already but her sister is only 6 so we have to keep it easy.
Twitter | Instagram |Facebook |Pinterest  Divider 989321gyey13hzitFree Native American Crochet Pattern for 18" Dolls♥ Pamela Barton // Adoring Doll Clothes
Free Native American Crochet Pattern for 18″ Dolls //
Instagram | Facebook | Pinterest | Twitter Divider 989321gyey13hzit

Best Picks from last weeks party

Across The Blvd Diy Fruit And Veggie Wall Baskets Feature Chosen By Clearissa // Clearissa’s Command Center
Across The Blvd // Diy Fruit And Veggie Wall Baskets
Divider 989321gyey13hzit The Kittchen How to Make RibollitaFeature Chosen by Indah // My Purple World
The Kittchen // How to Make Ribollita
Divider 989321gyey13hzit Nutz About Stamping How TO Create a Lovely Feminine CardFeature Chosen By Alice // DIYerfy
Nutz About Stamping // How To Create a Lovely Feminine Card
Divider 989321gyey13hzit The Kittchen Prosciutto Wrapped Mac and Cheese Bites with Cheez It CrumbsFeature Chosen By Amy // A Hippy and a Redneck
The Kittchen //Prosciutto Wrapped Mac and Cheese Bites with Cheez It Crumbs
Divider 989321gyey13hzit Tiered tray Valentine’s Day 8Feature Chosen By Kaycee // My Crafty Zoo
Living On Cloud Nine // Tiered Tray Valentine’s Day 8
Divider 989321gyey13hzit Crystal and Comp 21 Spaghetti Squash RcipesFeature Chosen by Suzan // SJ Country Crafts
Crystal and Comp // 21 Spaghetti Squash Recipes
Divider 989321gyey13hzit Birdseed Beggers From The Squirrel ClanFeature Chosen By Kaycee // My Crafty Zoo
God’s Growing Garden //Birdseed Beggers From The Squirrel ClanDivider 989321gyey13hzit Blogger Resource Feature Mamas Wallet How To Make Your First Affiliate Sale Online Even If You Are A NewbieFeature Chosen by Karren // Oh My Heartsie Girl
Mamas Wallet //How To Make Your First Affiliate Sale Online Even If You Are A Newbie Divider 989321gyey13hzit

There were so many wonderful Valentine posts in last few parties I wanted to share!

   But Now……Lets Party……

Please Take a Second To Share

 Where I Party
Mostly Blogging~Inspire Me Mondays // Imag-in-ing// Lou Lou Girls// Create With Joy WW Linky // Be There 2 Day//

Factors that Predict Poor Prognosis in SCD

Sickle cell disease (SCD) is a type of anemia that develops during birth due to the autosomal recessive mutation. In layman’s term, an abnormality will occur in the red blood cell structure and function. The autosomal recessive mutation occurs when the parents are positive carriers of the SCD. As a result, there’s a 25% chance that their child will inherit the disease.Factors that Predict Poor Prognosis in SCD

In this condition, the individual will have an irregular RBC is forming a crescent-like shape. The hemoglobin forms strands inside the red blood cell and causes the cell to deform into a crescent-like shape. The structure of the RBCs becomes a viscid causing blockage in the blood flow. Thus, the anemic condition will develop, and the symptoms will start to occur.

However, the sickle cell disease does not only concentrate on the red blood cells, but it may also cause damage to the heart, spleen, bone marrow, and other internal organs of the body. With this regard, how can the medical professionals treat this disease?

Prognostic Factors to Predict the Outcome of the Sickle Cell Disease

1. Etiology: Genotype and Phenotype Influences on the SCD

Chromosome 11 carries the gene-rich and disease-rich DNA makeup and each cell represents around 4% of the DNA structure. It is one of the 23 pairs of chromosomes that spans 135 million base pairs. The base pair is an essential building material for the DNA.

Normal hemoglobin has two subunits of amino acids present in its structure. These are known as the alpha and beta subunits. An individual experiencing SCD will usually have normal alpha subunits but abnormal beta subunits. What causes the beta subunit to be dysfunctional? It’s the alteration of the glutamic acid into Valine in position six present in Chromosome 11.

This further explains the genotype occurrences associated with the sickle cell disease. However, the phenotype occurrence may also influence the sickle cell disease to be aggravated or ameliorated. These are some of the causes that may have an impact on the SCD:

  • Changes in the Temperature Levels
  • Emotional Stress
  • High Altitude and Hypoxia
  • Infection (e.g. Parvovirus B19)
  • Dehydration
  • Cold Weather
  • Acidosis
  • Pregnancy
  • Alcohol Intoxication
  • Ingestion of toxins in the Bone Marrow (e.g. Phenylbutazone)

2. Histopathology: Understanding the Types of SCD Crises

A study and medical research must be performed to fully determine the medical attention needed to treat the SCD. However, you should understand the different types of SCD crises first to know the diseases associated with the SCD. Here are the following types of crises:

  1. Vaso-occlusive Crisis – this occurs when the sickle cell disease causes obstruction in the capillaries. It restricts the passage of the blow flow to the organs. Hence, this condition may further result in pain, damaged organ, ischemia, and necrosis.
  2. Aplastic Crisis – this happens when the parvovirus B19 invades the production of the red blood cells. It will multiply and destroy the RBCs causing fast heart-beat rate, paleness, and fatigue.
  3. Splenic Sequestration Crisis – it refers to the condition wherein there’s an enlargement of the spleen due to the increased risk of infection. With this regard, the spleen will find it difficult to remove the old RBCs and synthesize antibodies to fight the bacteria.
  4. Hemolytic Crisis – this occurs when there’s a sudden drop in the hemoglobin level due to the accelerated breakdown of the red blood cells. Generally, patients with G6PD deficiencies are prone to this condition.
  5. Acute Chest Syndrome – this is the inflammation of the lungs due to the infections and there’s a sudden saturation of the oxygen hence, sickling the RBCs. The patients will experience chest pain, focal abnormality, respiratory problems, fever, hypoxemia, and pulmonary infiltration.
  6. Dactylitis – it refers to the inflammation of the finger or toe due to the infections caused by the sickle cell anemia.

It is important to diagnose the patient as early as possible to know the associated diseases linked to the SCD. A health care provider and an expert doctor should always be accessible such as the Xpertdox.  In this way, the patient will be able to consult a licensed and expert physician as soon as possible to treat the disease.

3. Pathophysiology: Hemoglobin Molecules Polymerization

The autosomal recessive mutation can cause polymerization in the hemoglobin molecules that causes sickling of the RBCs. Aside from the genes, the phenotype phenomenon occurs that may cause the SCD, such as stress, fatigue, dehydration etc.…

These circumstances may develop high risks of getting a sickle cell disease because these issues may contribute to the reperfusion of the SCD.

  • Increase in the Potassium Levels
  • Gardo’s Channels
  • Increase Neutrophil adhesiveness
  • Increase Platelet activation
  • Changes in cation Homeostasis
  • Water Efflux
  • Nitric Oxide Binding
  • Hypercoagulability

4. Epidemiology: Survival and Control of the Disease

Sickle Cell Disease Statistics and Impact

According to the Centers for Disease Control and Prevention, the SCD causes health deprivation in almost millions of people throughout the world. Generally, the people affected with this disease lived in the United States, Saharan Africa, Western Hemisphere, India, the Mediterranean Basin, and Saudi Arabia. Even today, it is difficult to predict the exact number of people affected with this disease.

We have gathered the medical facts and scholarly research from the Centers for Disease Control and Prevention, and the National Center for Biotechnology Information. These are the latest estimates and statistics for the sickle cell disease carriers:

  • For every 1 out of 13 African-American infants were affected with a sickle cell trait.
  • For every 1 out of 16,300 Hispanic-American babies suffered from the SCD
  • For every 1 out of 500 African-American births suffered from an SCD condition
  • About 1 out of 12 African-American carry the autosomal recessive mutation
  • Approximately around 300,000 infants suffered from Sickle Cell Anemia

A thorough examination and laboratory diagnosis is a must to identify the origins of this disease. Instead of treating the disease itself, there should be prevented prior to the manifestation of the sickle cell disease.

Prevention and Control of the Sickle Cell Disease

Prevention and healthy living may contribute to a lesser chance of getting this disease. If you are affected or a carrier of this disease, you should pay attention to the basic healthy lifestyles. It is important to maintain a balanced diet, exercises vigorously, and sleep properly

You must undergo a series of laboratory tests to check your overall health condition. If you have associated diseases, you should discuss with your doctor. In some cases, doctors may advise you to undergo an imaging lab test, pharmacotherapy, and non-pharmacotherapy medications.

The main objective of the medications is to control and manage the symptoms and disease complications of the SCD. In this way, the patient can live longer and surpass the 40 to 60 age limits for the SCD. Here are the medication strategies for the sickle cell disease:

  • Treatment of the Pulmonary Hypertension
  • Detection and Prevention of the Infections
  • Treatment of the Damage Organs and Complications associated with the SCD
  • Detection and Prevention of Stroke
  • Treatment of the Chronic Pain Syndrome, Chronic Hemolytic Anemia, and Vaco-occlusive crisis

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